Article

A Self-Assembling Immune-Featured Osteosarcoma Patient/PDX Derived Organoid Model and Biobank for Personalized Immune Therapy

2024-08-11

Abstract excerpt

Osteosarcoma (OS) exhibit intra- and inter-heterogeneity, complicating the exploration of effective therapeutic strategies. Traditional in vitro and in vivo models are limited in inheriting biological and genomic heterogeneities of OS patients, even in inheriting the features on tumor microenvironment. The prolonged generation time of current models makes the drug development of OS slow and is not suitable to cl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a609cda-6500-53c6-a19a-e5f25d12e7b7
DOI: 10.1101/2024.08.11.607471

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Self-Assembling Immune-Featured Osteosarcoma Patient/PDX Derived Organoid Model and Biobank for Personalized Immune TherapyDOI 10.1101/2024.08.11.607471Read

A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacologySemantic proximity Read

Patient Derived Xenografts for Genome-Driven Therapy of OsteosarcomaSemantic proximity Read

A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacologySemantic proximity Read

Patient-derived osteosarcoma tumoroid model reveals functional phenotypic diversity with implications for drug responses.Semantic proximity Read

Patient-Derived Organoids Recapitulate Intrinsic Immune Landscapes and Progenitor Populations of GlioblastomaSemantic proximity Read

Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft modelsSemantic proximity Read

Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatmentSemantic proximity Read

Patient-derived urachal cancer organoids for personalized drug screeningSemantic proximity Read

Osteosarcoma: Molecular Pathogenesis and iPSC ModelingSemantic proximity Read

Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients.Semantic proximity Read

Whole-Exome Analysis and Osteosarcoma: A Game Still Open.Semantic proximity Read

Advances in Target Therapy Research in OsteosarcomaSemantic proximity Read