Article

GPCR-Gαq Signaling Drives Adaptive Resistance to MEK Inhibition in BRAF-Mutant Melanoma

2025-11-18

Abstract excerpt

Oncogenic BRAFV600E mutations drive constitutive MAPK signaling across various cancers; however, resistance to MEK inhibitors such as trametinib undermines clinical benefits, and the mechanisms sustaining MAPK activity under treatment remain unclear. We developed a lin-45(V627E) Caenorhabditis elegans model to mimic oncogenic BRAF signaling and found that these animals tolerate ultra-high doses of trametinib. Thi...

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Literature Corpus work: 41a691c8-a81a-5c16-92b6-ed06426492c6
DOI: 10.1101/2025.11.18.688995

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