Article

Quantitative Tyr Phosphoproteomic Analyses Identify Cholesterol as a Master Regulator of the Tumor Adaptive Resistance to MAPK Inhibition

2021-05-20

Abstract excerpt

Although targeted inhibition of the MAPK pathway has achieved remarkable patient responses in many cancers with MAPK hyperactivation, the development of resistance has remained a critical challenge. Besides genomic resistance mechanisms, adaptive tumor response also underlies the resistance to targeted MAPK inhibitors. It is being increasingly appreciated that such bypass mechanisms often lead to the activation of...

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Literature Corpus work: eda1706c-0aa2-5b28-8497-18c84e38c698
DOI: 10.1101/2021.05.20.444617

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