Article
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.
Nature reviews. Cancer - 1 Jun 2013
O'Hayre Morgan, Vázquez-Prado José, Kufareva Irina, Stawiski Eric W, Handel Tracy M, Seshagiri Somasekar, Gutkind J Silvio
Abstract excerpt
Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of tumours carry activating mutations in GNAS (encoding Gαs), and that oncogenic activating mutations in genes encoding Gαq family members (GNAQ or GNA11) are present in ~66% and ~6% of melanomas arising in the eye and skin, respectively....
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