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Article

Functional distinction in oncogenic Ras variant activity in Caenorhabditis elegans.

Disease models & mechanisms - 1 Aug 2024

Lyu Haimeng, Chamberlin Helen M

Abstract excerpt

Ras genes are important oncogenes that are frequently mutated in cancer. Human oncogenic variants exhibit functional distinctions in terms of their representation in different cancer types, impact on cellular targets and sensitivity to pharmacological treatments. However, how these distinct variants influence and respond to the cellular networks in which they are embedded is poorly understood. To identify novel...

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Identifiers

PMID: 38946472
DOI: 10.1242/dmm.050577
PMCID: PMC11340813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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