Article

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

2021-06-14

Abstract excerpt

Very high risk neuroblastoma is characterised by increased MAPK signalling, and targeting MAPK signalling is a promising therapeutic strategy. We used a deeply characterised panel of neuroblastoma cell lines and found that the sensitivity to MEK inhibitors varied drastically between these cell lines. By generating quantitative perturbation data and mathematical modelling, we determined potential resistance mechani...

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Literature Corpus work: ca282f89-f0c8-5ceb-af4e-60f8e287b6b7
DOI: 10.1101/2021.06.14.448322

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