Article

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

2024-10-25

Abstract excerpt

Mitochondrial electron transport flavoprotein (ETF) insufficiency causes metabolic diseases known as a multiple acyl-CoA dehydrogenase deficiency (MADD). In contrast to muscle, ETFDH is a non-essential gene in acute lymphoblastic leukemia NALM-6 cells, and its expression is reduced across human cancers. ETF insufficiency caused by decreased ETFDH expression limits flexibility of OXPHOS fuel utilization but paradox...

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Identifiers and source

Literature Corpus work: 418f1fdc-168a-549c-9161-b4fb9071afe0
DOI: 10.1101/2024.10.25.620155

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