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Article

The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells

28 Jul 2020

Abstract excerpt

Mitochondria are signaling hubs in eukaryotic cells. Here, we showed that the mitochondrial FUN14 domain-containing protein-1 (FUNDC1), an effector of Parkin-independent mitophagy, also participates in cellular plasticity by sustaining oxidative bioenergetics, buffering ROS production, and supporting cell proliferation. Targeting this pathway in cancer cells suppressed tumor growth but rendered transformed cells...

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Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
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PMID: 32723812
DOI: 10.1126/scisignal.aaz8240

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