Article

Bub1 kinase acts as a signalling hub for the entire <i>Cryptococcus neoformans</i> spindle assembly checkpoint pathway

2022-09-21

Abstract excerpt

Cryptococcus neoformans ( Cn ) is an important human pathogen and a model system for basidiomycetes. Here we carry out a dissection of its spindle assembly checkpoint (SAC), focusing on Bub1 and Bub3. In many eukaryotes, including humans, Saccharomyces cerevisiae and Schizosaccharomyces pombe , Bub1 underwent gene duplication, generating paralogues referred to as Bub1 and BubR1 (or Mad3). Bub1 has upstream sign...

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Literature Corpus work: 41846e1b-4beb-5578-a150-1317b6091ada
DOI: 10.1101/2022.09.21.508923

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