Extrachromosomal circular DNA orchestrates genome heterogeneity in urothelial bladder carcinoma.

doi:10.7150/thno.99563

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Article

Extrachromosomal circular DNA orchestrates genome heterogeneity in urothelial bladder carcinoma.

Theranostics - 1 Jan 2024

Lv Wei, Pan Xiaoguang, Han Peng, Wu Shuang, Zeng Yuchen, Wang Qingqing, Guo Lidong, Xu Mengyang, Qi Yanwei, Deng Li, Xu Zhe, Li Conghui, Yu Tianxi, Cui Xin, Teng Huajing, Xiang Chongjun, Tan Haotian, Li Yue, Liang Ning, Tao Huiying, Gao Qingqing, Yu Guohua, Mi Jia, Xu Fuyi, Gong Benjiao, Shi Lei, Wang Tao, Yang Huanming, Dong Wei, Bolund Lars, Lin Lin, Wang Wenting, Li Hanbo, Huang Jinrong, Lin Chunhua, Luo Yonglun

Abstract excerpt

Rationale: Extrachromosomal circular DNA is a hallmark of cancer, but its role in shaping the genome heterogeneity of urothelial bladder carcinoma (UBC) remains poorly understood. Here, we comprehensively analyzed the features of extrachromosomal circular DNA in 80 UBC patients. Methods: We performed whole-genome/exome sequencing (WGS/WES), Circle-Seq, single-molecule real-time (SMRT) long-read sequencing of...

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PMID: 39267784
DOI: 10.7150/thno.99563
PMCID: PMC11388072

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