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Dissecting the shared genetic architecture of bipolar disorder, major depressive disorder, and attention-deficit hyperactivity disorder.

PloS one - 1 Jan 2026

Lawrence Christopher, Hansen Thomas Folkmann

Abstract excerpt

Major depressive disorder (MDD), bipolar disorder (BPD), and attention-deficit hyperactivity disorder (ADHD) are prevalent, highly heritable psychiatric disorders with significant degrees of genetic overlap. Using open-sourced summary statistics from the Psychiatric Genomics Consortium and 1000 Genomes European reference panel, we fit a latent factor model (F1) capturing the shared genetic liability across MDD,...

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Attention Deficit Disorder with Hyperactivity
Bipolar Disorder
Genetic Predisposition to Disease
Genome-Wide Association Study
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Major Depressive Disorder

Polymorphism, Single Nucleotide

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PMID: 41729977
DOI: 10.1371/journal.pone.0333571
PMCID: PMC12928397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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