Article

Transcriptomic profiling of the human habenula reveals a shared molecular architecture across mood disorders

2026-06-03

Abstract excerpt

The habenula is a critical regulator of monoaminergic and reward circuitry and is increasingly implicated in the neurobiology of mood disorders. Preclinical studies demonstrate that habenula hyperactivity drives depressive-like behaviours and can be reversed by interventions such as ketamine and deep brain stimulation. However, the molecular architecture of the human habenula remains largely unexplored. Here, we a...

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Literature Corpus work: 5854e733-f005-5bdb-9569-c2455b962697
DOI: 10.64898/2026.06.01.728671

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