Article

The structure of pathogenic huntingtin exon-1 defines the bases of its aggregation propensity

2022-10-26

Abstract excerpt

Huntington’s Disease is a neurodegenerative disorder caused by a CAG expansion of the first exon of the HTT gene, resulting in an extended poly-glutamine (poly-Q) tract in the N-terminus of the protein huntingtin (httex1). The structural changes occurring to the poly-Q when increasing its length remain poorly understood mainly due to its intrinsic flexibility and the strong compositional bias of the protein. The...

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Literature Corpus work: a8bf25bb-d8a6-54fe-932c-4f7afa7ce016
DOI: 10.1101/2022.10.25.513661

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