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Article

The structural impact of a polyglutamine tract is location-dependent.

Biophysical journal - 15 Dec 2008

Robertson Amy L, Horne James, Ellisdon Andrew M, Thomas Bronwen, Scanlon Martin J, Bottomley Stephen P

Abstract excerpt

Polyglutamine (polyQ) expansion leads to protein aggregation and neurodegeneration in Huntington's disease and eight other inherited neurological conditions. Expansion of the polyQ tract beyond a threshold of 37 glutamines leads to the formation of toxic nuclear aggregates. This suggests that polyQ expansion causes a conformational change within the protein, the nature of which is unclear. There is a trend in the...

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Identifiers

PMID: 18849414
DOI: 10.1529/biophysj.108.138487
PMCID: PMC2599835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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