Article

Norvaline reduces blood pressure and induces diuresis in rats with inherited stress-induced arterial hypertension

2019-06-21

Abstract excerpt

Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects of arginase are associated with a severe decline in L-arginine bioavailability, which leads to nitric oxide synthase substrate insufficiency, uncoupling, and, eventually, to superoxide anion generation and substantial...

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Literature Corpus work: 4132c590-b879-5137-9578-bb8eb0d3c83a
DOI: 10.1101/678839

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