Article
Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage.
Circulation - 1 Jan 2002
Shimosawa Tatsuo, Shibagaki Yugo, Ishibashi Kotaro, Kitamura Kazuo, Kangawa Kenji, Kato Shigeaki, Ando Katsuyuki, Fujita Toshiro
Abstract excerpt
BACKGROUND: Adrenomedullin (AM), a potent vasodilator peptide, is produced by posttranslational splicing of pro-adrenomedullin together with proadrenomedullin N-terminal 20 peptide (PAMP), another hypotensive peptide. Although both AM and PAMP have the potential not only to decrease blood pressure but also to protect organs from damage, there is no direct evidence for their individual physiological roles in vivo....
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