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Whole Organism High Content Screening Identifies Stimulators of Pancreatic Beta-Cell Proliferation

12 Aug 2014

Abstract excerpt

Inducing beta-cell mass expansion in diabetic patients with the aim to restore glucose homeostasis is a promising therapeutic strategy. Although several in vitro studies have been carried out to identify modulators of beta-cell mass expansion, restoring endogenous beta-cell mass in vivo has yet to be achieved. To identify potential stimulators of beta-cell replication in vivo, we established transgenic zebrafish...

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PMID: 25117518
DOI: 10.1371/journal.pone.0104112

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