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<i>In silico</i> discovery of small molecules for efficient stem cell differentiation into definitive endoderm

2021-10-09

Abstract excerpt

<h4>Summary</h4> Improving methods for human embryonic stem cell differentiation represents a challenge in modern regenerative medicine research. Using drug repurposing approaches, we discover small molecules that regulate the formation of definitive endoderm. Among them are inhibitors of known processes involved in endoderm differentiation (mTOR, PI3K, and JNK pathways) and a new compound, with an unknown mechan...

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Literature Corpus work
8d4f9536-a1df-5102-876a-fe0b387b3e1d
DOI
10.1101/2021.10.06.463418
Open publication

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<i>In silico</i> discovery of small molecules for efficient stem cell differentiation into definitive endodermDOI 10.1101/2021.10.06.463418
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