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Cell type-focused compound screen in human organoids reveals CK1 and MAPK11 inhibition protects cone photoreceptors from death

2023-10-10

Abstract excerpt

<h4>SUMMARY</h4> Human organoids that mirror their corresponding organs in cell-type diversity present an opportunity to perform large-scale screens for compounds that protect disease-affected or damage healthy cell types. However, such screens have not yet been performed. Here, we generated 20,000 human retinal organoids with GFP-labeled cone photoreceptors. Since degeneration of cones is a leading cause of blin...

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Identifiers and source

Literature Corpus work
4114e520-2f36-50da-92d7-1fbb145d31ab
DOI
10.1101/2023.10.09.561525
Open publication

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Cell type-focused compound screen in human organoids reveals CK1 and MAPK11 inhibition protects cone photoreceptors from deathDOI 10.1101/2023.10.09.561525
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