Article
YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 May 2020
Rudolf Mark A, Andreeva Anna, Kozlowski Mikolaj M, Kim Christina E, Moskowitz Bailey A, Anaya-Rocha Alejandro, Kelley Matthew W, Corwin Jeffrey T
Abstract excerpt
Loss of sensory hair cells causes permanent hearing and balance deficits in humans and other mammals, but for nonmammals such deficits are temporary. Nonmammals recover hearing and balance sensitivity after supporting cells proliferate and differentiate into replacement hair cells. Evidence of mechanical differences between those sensory epithelia and their supporting cells prompted us to investigate whether the...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Animals, Newborn
- Cell Cycle Proteins
- Cell Proliferation
- Chick Embryo
- Chickens
- Gene Deletion
- Genetic Variation
- Hair Cells, Auditory