Article
Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2019
McCarthy Michael J, Wei Heather, Nievergelt Caroline M, Stautland Andrea, Maihofer Adam X, Welsh David K, Shilling Paul, Alda Martin, Alliey-Rodriguez Ney, Anand Amit, Andreasson Ole A, Balaraman Yokesh, Berrettini Wade H, Bertram Holli, Brennand Kristen J, Calabrese Joseph R, Calkin Cynthia V, Claasen Ana, Conroy Clara, Coryell William H, Craig David W, D'Arcangelo Nicole, Demodena Anna, Djurovic Srdjan, Feeder Scott, Fisher Carrie, Frazier Nicole, Frye Mark A, Gage Fred H, Gao Keming, Garnham Julie, Gershon Elliot S, Glazer Kara, Goes Fernando, Goto Toyomi, Harrington Gloria, Jakobsen Petter, Kamali Masoud, Karberg Elizabeth, Kelly Marisa, Leckband Susan G, Lohoff Falk, McInnis Melvin G, Mondimore Francis, Morken Gunnar, Nurnberger John I, Obral Sarah, Oedegaard Ketil J, Ortiz Abigail, Ritchey Megan, Ryan Kelly, Schinagle Martha, Schoeyen Helle, Schwebel Candice, Shaw Martha, Shekhtman Tatyana, Slaney Claire, Stapp Emma, Szelinger Szabolcs, Tarwater Bruce, Zandi Peter P, Kelsoe John R
Abstract excerpt
Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic...
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