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Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation

4 Jul 2023

Abstract excerpt

Abstract While most of the efforts to uncover mechanisms contributing to bipolar disorder (BD) focused on phenotypes at the mature neuron stage, little research has considered events that may occur during earlier timepoints of neurodevelopment. Further, although aberrant calcium (Ca 2+ ) signaling has been implicated in the etiology of this condition, the possible contribution of store-operated Ca 2+ entry (SOCE)...

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PMID: 37402854
DOI: 10.1038/s41380-023-02152-6

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