Article

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

2021-10-21

Abstract excerpt

<title>Abstract</title> <p>Perivascular space burden (PVS) is an emerging and possibly the earliest magnetic resonance imaging (MRI)-marker of cerebral small vessel disease (cSVD), a leading cause of stroke and dementia. Its molecular underpinnings are unknown. Genome-wide and whole-exome association studies in 40,095 participants (21 population-based cohorts, 66.3±8.6 years) revealed 24 genome-wide significant P...

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Literature Corpus work: f990ee96-0fc6-556f-9b1e-84417b87c68b
DOI: 10.21203/rs.3.rs-963149/v1

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