Article

Structural development of amyloid precursors in insulin B chain and the inhibition effect by fibrinogen

2021-12-27

Abstract excerpt

Amyloid fibrils are abnormal protein aggregates that relate to a large number of amyloidoses and neurodegenerative diseases. The oligomeric precursors, or prefibrillar intermediates, which emerge prior to the amyloid fibril formation, have been known to play a crucial role for the formation. Therefore, it is essential to elucidate the mechanisms of the structural development of the prefibrillar intermediates and w...

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Literature Corpus work: 40b4449f-1eed-540a-ba28-43025bb85db6
DOI: 10.1101/2021.12.26.474222

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