Article

Multistep changes in amyloid structure that are induced by cross-seeding on a rugged energy landscape

2020-07-19

Abstract excerpt

<h4>ABSTRACT</h4> Amyloid fibrils are aberrant protein aggregates associated with various amyloidoses and neurodegenerative diseases. It is recently indicated that structural diversity of amyloid fibrils often results in different pathological phenotypes including cytotoxicity and infectivity. The diverse structures are predicted to propagate by seed-dependent growth, which is one of the characteristic properties...

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Literature Corpus work: d57d4361-a4e1-5d00-9af0-632e26f42426
DOI: 10.1101/2020.07.19.211284

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