Article
Time-resolved small-angle x-ray scattering study of the early stage of amyloid formation of an apomyoglobin mutant.
Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Dec 2011
Ortore Maria Grazia, Spinozzi Francesco, Vilasi Silvia, Sirangelo Ivana, Irace Gaetano, Shukla Anuj, Narayanan Theyencheri, Sinibaldi Raffaele, Mariani Paolo
Abstract excerpt
The description of the fibrillogenesis pathway and the identification of "on-pathway" or "off-pathway" intermediates are key issues in amyloid research as they are concerned with the mechanism for onset of certain diseases and with therapeutic treatments. Recent results on the fibril formation process revealed an unexpected complexity both in the number and in the types of species involved, but the early...
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