Article

Studies on Oxidative Damage of the Wobble 5-methylcarboxymethyl-2-thiouridine in tRNA of Eukaryotic Cells with Disturbed Homeostasis of the Antioxidant System

2024-10-28

Abstract excerpt

We have previously shown that 2-thiouridine (S2U), either as a single nucleoside or as an element of RNA chain, is effectively desulfurized under applied in vitro oxidative conditions. Chemically induced desulfuration of S2U resulted in two products: 4-pyrimidinone nucleoside (H2U) and uridine (U). Recently, we investigated whether desulfuration of S2U is a natural process that also occurs in cells exposed to oxid...

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Literature Corpus work: 4097d248-e6b1-57a4-9902-3113cebb5474
DOI: 10.20944/preprints202410.2206.v1

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