Article

Potential immunosuppressive clonal hematopoietic mutations in tumor infiltrating immune cells in breast invasive carcinoma

2022-11-28

Abstract excerpt

A hallmark of cancer is a tumor cell’s ability to evade immune destruction. Somatic mutations in tumor cells that prevent immune destruction have been extensively studied. However, somatic mutations in tumor infiltrating immune (TII) cells , to our knowledge, have not been previously studied. Understandably so since normal hematopoiesis prevents the accumulation of somatic mutations in immune cells. However, clona...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 406d5496-39bf-5984-b81c-4a734840d6a9
DOI: 10.21203/rs.3.rs-2289793/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Potential immunosuppressive clonal hematopoietic mutations in tumor infiltrating immune cells in breast invasive carcinomaDOI 10.21203/rs.3.rs-2289793/v1Read

Potential immunosuppressive clonal hematopoietic mutations in tumor infiltrating immune cells in breast invasive carcinoma.Semantic proximity Read

Integrated analysis of somatic mutations and immune microenvironment of multiple regions in breast cancersSemantic proximity Read

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapySemantic proximity Read

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy responseSemantic proximity Read

Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8+/PDL1+ Immune Infiltration in Inflammatory Breast Cancer Tumors.Semantic proximity Read

Immuno-oncology from the perspective of somatic evolution.Semantic proximity Read

Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivitySemantic proximity Read

Genetic immune escape landscape in primary and metastatic cancerSemantic proximity Read

Characterization of Stromal Tumor-infiltrating Lymphocytes and Genomic Alterations in Metastatic Lobular Breast Cancer.Semantic proximity Read

Whole-exome sequencing identifies somatic mutations and intratumor heterogeneity in inflammatory breast cancerSemantic proximity Read

Genetic immune escape landscape in primary and metastatic cancerSemantic proximity Read

Blood-based screening panel for lung cancer based on clonal hematopoietic mutationsSemantic proximity Read