Article
Potential immunosuppressive clonal hematopoietic mutations in tumor infiltrating immune cells in breast invasive carcinoma.
Scientific reports - 12 Aug 2023
Anandakrishnan Ramu, Zyvoloski Ian J, Zyvoloski Lucas R, Opoku Nana K, Dai Andrew, Antony Veneeth
Abstract excerpt
A hallmark of cancer is a tumor cell's ability to evade immune destruction. Somatic mutations in tumor cells that prevent immune destruction have been extensively studied. However, somatic mutations in tumor infiltrating immune (TII) cells, to our knowledge, have not been previously studied. Understandably so since normal hematopoiesis prevents the accumulation of somatic mutations in immune cells. However,...
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