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Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8+/PDL1+ Immune Infiltration in Inflammatory Breast Cancer Tumors.

Molecular cancer therapeutics - 1 Jul 2016

Hamm Christopher A, Moran Diarmuid, Rao Kakuturu, Trusk Patricia B, Pry Karen, Sausen Mark, Jones Siân, Velculescu Victor E, Cristofanilli Massimo, Bacus Sarah

Abstract excerpt

Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that remains poorly understood at the molecular level. Comprehensive tumor profiling was performed to understand clinically actionable alterations in IBC. Targeted next-generation sequencing (NGS) and IHC were performed to identify activated pathways in IBC tumor tissues. siRNA studies examined the impact of IBC genomic variants in...

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PMID: 27196778
DOI: 10.1158/1535-7163.MCT-15-0353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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