Article

TF-TWAS: Transcription-factor polymorphism associated with tissue-specific gene expression

2018-08-31

Abstract excerpt

Transcriptional regulation is associated with a broad range of diseases. Methods associating genetic polymorphism with gene transcription levels offer key insights for understanding the transcriptional regulation plan. The majority of gene imputation methods focus on modeling polymorphism in the cis regions of the gene, partially owing to the large genetic search space. We hypothesize that polymorphism within tra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 406d05bc-8864-57ac-8278-cb684f1b89c3
DOI: 10.1101/405936

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TF-TWAS: Transcription-factor polymorphism associated with tissue-specific gene expressionDOI 10.1101/405936Read

Enhancing Disease Risk Gene Discovery by Integrating Transcription Factor-Linked Trans-located Variants into Transcriptome-Wide Association AnalysesSemantic proximity Read

Enhancing disease risk gene discovery by integrating transcription factor-linked trans-variants into transcriptome-wide association analyses.Semantic proximity Read

Transcription factor regulation of eQTL activity across individuals and tissuesSemantic proximity Read

Identifying Genetic Regulatory Variants that Affect Transcription Factor ActivitySemantic proximity Read

Predicting genotype-specific gene regulatory networks.Semantic proximity Read

Predicting genotype-specific gene regulatory networksSemantic proximity Read

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritabilitySemantic proximity Read

Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers.Semantic proximity Read

TIGAR-V2: Efficient TWAS Tool with Nonparametric Bayesian eQTL Weights of 49 Tissue Types from GTEx V8Semantic proximity Read

Transcription factor regulation of eQTL activity across individuals and tissues.Semantic proximity Read

Predicting tissue-specific gene expression from whole blood transcriptomeSemantic proximity Read

Partitioning and aggregating cross-tissue and tissue-specific genetic effects to identify gene-trait associations.Semantic proximity Read