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Article

Transcription factor regulation of eQTL activity across individuals and tissues.

PLoS genetics - 1 Jan 2022

Flynn Elise D, Tsu Athena L, Kasela Silva, Kim-Hellmuth Sarah, Aguet Francois, Ardlie Kristin G, Bussemaker Harmen J, Mohammadi Pejman, Lappalainen Tuuli

Abstract excerpt

Tens of thousands of genetic variants associated with gene expression (cis-eQTLs) have been discovered in the human population. These eQTLs are active in various tissues and contexts, but the molecular mechanisms of eQTL variability are poorly understood, hindering our understanding of genetic regulation across biological contexts. Since many eQTLs are believed to act by altering transcription factor (TF) binding...

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Identifiers

PMID: 35100260
DOI: 10.1371/journal.pgen.1009719
PMCID: PMC8830792

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