Article
Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers.
Nature communications - 19 Nov 2022
He Jingni, Wen Wanqing, Beeghly Alicia, Chen Zhishan, Cao Chen, Shu Xiao-Ou, Zheng Wei, Long Quan, Guo Xingyi
Abstract excerpt
Transcriptome-wide association studies (TWAS) have successfully discovered many putative disease susceptibility genes. However, TWAS may suffer from inaccuracy of gene expression predictions due to inclusion of non-regulatory variants. By integrating prior knowledge of susceptible transcription factor occupied elements, we develop sTF-TWAS and demonstrate that it outperforms existing TWAS approaches in both...
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