Article

Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer

2023-08-02

Abstract excerpt

The cancer associated cachexia syndrome (CACS) is a systemic metabolic disorder resulting in loss of body weight due to skeletal muscle and adipose tissues atrophy. CACS is particularly prominent in lung cancer patients, where it contributes to poor quality of life and excess mortality. Using the Kras/Lkb1 (KL) mouse model, we found that CACS is associated with white adipose tissue (WAT) dysfunction that directly...

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Identifiers and source

Literature Corpus work: 40690926-8231-5a2f-b439-c8b89425e1a9
DOI: 10.1101/2023.07.31.551241

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