Article

Pathophysiological remodeling of the skeletal muscle microenvironment in patients with lung cancer

2025-11-20

Abstract excerpt

Cancer-associated cachexia is characterized by weight loss, muscle wasting, systemic inflammation, and functional decline. This multifactorial syndrome is highly prevalent and detrimental in patients with advanced-stage non–small cell lung cancer (NSCLC). To investigate the cellular and molecular underpinnings of muscle wasting, we analyzed skeletal muscle biopsies from NSCLC patients and healthy matched controls...

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Literature Corpus work: 5c22de84-38b3-5332-b43c-6dad289e204f
DOI: 10.1101/2025.11.19.689342

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