Article

Multiscale causal network models of Alzheimer’s disease identify VGF as a key regulator of disease

2018-11-04

Abstract excerpt

Though discovered over 100 years ago, the molecular foundation of sporadic Alzheimer’s disease (AD) remains elusive. To elucidate its complex nature, we constructed multiscale causal network models on a large human AD multi-omics dataset, integrating clinical features of AD, DNA variation, and gene and protein expression into probabilistic causal models that enabled detection and prioritization of high-confidence...

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Literature Corpus work: 4057577c-b756-577d-a54d-b74c42a5ae55
DOI: 10.1101/458430

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