Article

Validation of a Mitochondrial Polygenic Score for Parkinson’s Disease

2025-03-19

Abstract excerpt

<h4>Background</h4> Mitochondrial dysfunction is a key player in Parkinson’s disease (PD) pathogenesis. Mitochondrial polygenic scores (MGS) may be associated with PD but require validation across diverse populations. <h4>Objective</h4> To validate the association between the MGS, PD status and age-at-onset (AAO) in idiopathic and LRRK2- PD across various ancestries. <h4>Methods</h4> We analyzed data from 17,129 P...

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Literature Corpus work: 767631d8-1a44-5eb2-80d5-adf4fb25eced
DOI: 10.1101/2025.03.18.25323898

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