Article

Genetic variation within genes associated with mitochondrial function is significantly associated with later age at onset of Parkinson disease and contributes to disease risk

2018-12-04

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial dysfunction has been implicated in the aetiology of monogenic Parkinson’s disease (PD). Yet the role that mitochondrial processes play in the most common form of the disease; sporadic PD, is yet to be fully established. Here we comprehensively assessed the role of mitochondrial function associated genes in sporadic PD by leveraging improvements in the scale and analysis of PD GWAS...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d39c69f-c1a3-536f-8d5b-7848373f90dd
DOI: 10.1101/475111

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic variation within genes associated with mitochondrial function is significantly associated with later age at onset of Parkinson disease and contributes to disease riskDOI 10.1101/475111Read

Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onsetSemantic proximity Read

Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson’s diseaseSemantic proximity Read

Rare genetic variation in mitochondrial pathways influences the risk for Parkinson's diseaseSemantic proximity Read

Enrichment of Rare Variants in Nuclear-Encoded Mitochondrial Metabolism Genes in Patients with Early-Onset or Familial Parkinson's Disease.Semantic proximity Read

Genetic landscape of Parkinson’s disease in the Personalized Parkinson Project cohortSemantic proximity Read

Parkinson's Disease, Parkinsonisms, and Mitochondria: the Role of Nuclear and Mitochondrial DNA.Semantic proximity Read

Recent advances in Parkinson’s disease genetics.Semantic proximity Read

The impact of genetic research on our understanding of Parkinson's disease.Semantic proximity Read

Nuclear Genes Associated with Mitochondrial DNA Processes as Contributors to Parkinson's Disease RiskSemantic proximity Read

Genetic Insights into Sporadic Parkinson's Disease PathogenesisSemantic proximity Read

Polygenic Risk Scores Validated in Patient-Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease.Semantic proximity Read

Genetic landscape of Parkinson’s disease and related diseases in LuxembourgSemantic proximity Read