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Article

Rare genetic variation in mitochondrial pathways influences the risk for Parkinson's disease

5 Sept 2018

Abstract excerpt

ABSTRACT Background: Mitochondrial dysfunction plays a key role in PD, but the underlying molecular mechanisms remain unresolved. We hypothesized that the disruption of mitochondrial function in PD is primed by rare, protein‐altering variation in nuclear genes controlling mitochondrial structure and function. Objective: The objective of this study was to assess whether genetic variation in genes associated with...

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PMID: 30256453
DOI: 10.1002/mds.64

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