Article

Novel mitochondrial variants associated with Parkinson’s disease reveal a high heteroplasmy-weighted polygenic risk score in Brazilians

2026-01-16

Abstract excerpt

Mitochondrial single-nucleotide variants (mtSNVs) can dysregulate cellular bioenergetics and have been increasingly implicated in susceptibility to Parkinson’s disease (PD). These variants may impair oxidative metabolism and respiratory chain efficiency, thus contributing to neuronal dysfunction and degeneration. In peripheral blood, mtSNVs may also reflect systemic immunometabolic alterations associated with PD;...

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Literature Corpus work: f38a410a-f858-5d9c-a603-e124c4cee58f
DOI: 10.64898/2026.01.15.26344224

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