Article

Circadian Regulator PER2 Protects Against Epithelial Necroptosis in Ulcerative Colitis via the STAT1–ZBP1 Axis

2025-10-12

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by epithelial barrier disruption, excessive cell death, and dysregulated immune signaling. While circadian rhythms are known to influence immune homeostasis, the role of the core circadian regulator Period circadian clock 2 (PER2) in intestinal inflammation remains poorly understood...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 879fb33d-8f02-57fd-929d-3b962da132f5
DOI: 10.21203/rs.3.rs-7601246/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Circadian Regulator PER2 Protects Against Epithelial Necroptosis in Ulcerative Colitis via the STAT1–ZBP1 AxisDOI 10.21203/rs.3.rs-7601246/v1Read

Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine.Semantic proximity Read

Systematic analysis of circadian genes using genome-wide cDNA microarrays in the inflammatory bowel disease transcriptomeSemantic proximity Read

Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammationSemantic proximity Read

Colonic inflammation modulates the intestinal circadian landscapeSemantic proximity Read

Uncovering the Novel Role of NR1D1 in Regulating BNIP3-Mediated Mitophagy in Ulcerative ColitisSemantic proximity Read

The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer developmentSemantic proximity Read

Circadian clock-related genome-wide Mendelian randomization identifies putatively genes for ulcerative colitis and its comorbiditySemantic proximity Read

Relationship between the Biological Clock and Inflammatory Bowel DiseaseSemantic proximity Read

Therapeutic Strategies for Anti-TNF Non-Responsive IBD PatientsSemantic proximity Read

Ontogeny and function of the circadian clock in intestinal organoidsSemantic proximity Read

Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammationSemantic proximity Read

Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammationSemantic proximity Read