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PIM1–HDAC2 axis modulates intestinal homeostasis through epigenetic modification

23 Apr 2024

Abstract excerpt

The mucosal barrier is crucial for intestinal homeostasis, and goblet cells are essential for maintaining the mucosal barrier integrity. The proviral integration site for Moloney murine leukemia virus-1 (PIM1) kinase regulates multiple cellular functions, but its role in intestinal homeostasis during colitis is unknown. Here, we demonstrate that PIM1 is prominently elevated in the colonic epithelia of both...

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PMID: 39027246
DOI: 10.1016/j.apsb.2024.04.017

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