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Article

The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2014

Turgeon Naomie, Gagné Julie Moore, Blais Mylène, Gendron Fernand-Pierre, Boudreau François, Asselin Claude

Abstract excerpt

Histone deacetylases (Hdac) remove acetyl groups from proteins, influencing global and specific gene expression. Hdacs control inflammation, as shown by Hdac inhibitor-dependent protection from dextran sulfate sodium (DSS)-induced murine colitis. Although tissue-specific Hdac knockouts show redundant and specific functions, little is known of their intestinal epithelial cell (IEC) role. We have shown previously...

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Identifiers

PMID: 24525021
DOI: 10.1152/ajpgi.00393.2013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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