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Article

Nonlinear dimension reduction with Wright-Fisher kernel for genotype aggregation and association mapping.

Bioinformatics (Oxford, England) - 15 Sept 2012

Zhu Hongjie, Li Lexin, Zhou Hua

Abstract excerpt

MOTIVATION: Association tests based on next-generation sequencing data are often under-powered due to the presence of rare variants and large amount of neutral or protective variants. A successful strategy is to aggregate genetic information within meaningful single-nucleotide polymorphism (SNP) sets, e.g. genes or pathways, and test association on SNP sets. Many existing methods for group-wise tests require...

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Identifiers

PMID: 22962455
DOI: 10.1093/bioinformatics/bts406
PMCID: PMC3436833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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