More powerful genetic association testing via a new statistical framework for integrative genomics.

Abstract excerpt

Integrative genomics offers a promising approach to more powerful genetic association studies. The hope is that combining outcome and genotype data with other types of genomic information can lead to more powerful SNP detection. We present a new association test based on a statistical model that explicitly assumes that genetic variations affect the outcome through perturbing gene expression levels. It is shown...

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• Algorithms
• Computer Simulation
• DNA Mutational Analysis
• Genetic Association Studies
• Models, Genetic