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Identifying complex gene-gene interactions: a mixed kernel omnibus testing approach.

Briefings in bioinformatics - 5 Nov 2021

Liu Yan, Gao Yuzhao, Fang Ruiling, Cao Hongyan, Sa Jian, Wang Jianrong, Liu Hongqi, Wang Tong, Cui Yuehua

Abstract excerpt

Genes do not function independently; rather, they interact with each other to fulfill their joint tasks. Identification of gene-gene interactions has been critically important in elucidating the molecular mechanisms responsible for the variation of a phenotype. Regression models are commonly used to model the interaction between two genes with a linear product term. The interaction effect of two genes can be...

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PMID: 34373892
DOI: 10.1093/bib/bbab305

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