Article

Mechanism of Mycolactone Toxin Membrane Permeation: Atomistic vs Coarse-Grained MARTINI Simulations

2018-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Mycolactone, a cytotoxic and immunosuppressive macrolide produced by Mycobacterium ulcerans , is the central virulent factor in the skin disease Buruli ulcer. This multifunctional cytotoxin affects fundamental cellular processes such as cell adhesion, immune response and cell death by targeting various cellular structures. Developing effective diagnostics that target mycolactone has been challe...

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Literature Corpus work: 403b3663-b352-50ce-bcec-55469a2a4aac
DOI: 10.1101/470807

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