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Substrate access mechanism in a novel membrane-bound phospholipase A of <i>Pseudomonas aeruginosa</i> concordant with specificity and regioselectivity

2021-06-29

Abstract excerpt

PlaF is a cytoplasmic membrane-bound phospholipase A 1 from Pseudomonas aeruginosa that alters the membrane glycerophospholipid (GPL) composition and fosters the virulence of this human pathogen. PlaF activity is regulated by a dimer-to-monomer transition followed by tilting of the monomer in the membrane. However, how substrates reach the active site and how the characteristics of the active site tunnels determ...

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Literature Corpus work
a7d4c914-5cd8-596c-846b-9fa77fcdeded
DOI
10.1101/2021.06.29.450291
Open publication

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Substrate access mechanism in a novel membrane-bound phospholipase A of <i>Pseudomonas aeruginosa</i> concordant with specificity and regioselectivityDOI 10.1101/2021.06.29.450291
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