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Article

Bridging timescales and length scales: from macroscopic flux to the molecular mechanism of antibiotic diffusion through porins.

Biophysical journal - 17 Feb 2010

Hajjar Eric, Mahendran Kozhinjampara R, Kumar Amit, Bessonov Andrey, Petrescu Mircea, Weingart Helge, Ruggerone Paolo, Winterhalter Mathias, Ceccarelli Matteo

Abstract excerpt

Our aim in this study was to provide an atomic description of ampicillin translocation through OmpF, the major outer membrane channel in Escherichia coli and main entry point for beta-lactam antibiotics. By applying metadynamics simulations, we also obtained the energy barriers along the diffusio...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20159153
DOI: 10.1016/j.bpj.2009.10.045
PMCID: PMC2820638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20159153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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