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Article

The Hippo pathway regulates density-dependent proliferation of iPSC-derived cardiac myocytes.

Scientific reports - 7 Sept 2021

Neininger Abigail C, Dai Xiaozhaun, Liu Qi, Burnette Dylan T

Abstract excerpt

Inducing cardiac myocytes to proliferate is considered a potential therapy to target heart disease, however, modulating cardiac myocyte proliferation has proven to be a technical challenge. The Hippo pathway is a kinase signaling cascade that regulates cell proliferation during the growth of the heart. Inhibition of the Hippo pathway increases the activation of the transcription factors YAP/TAZ, which translocate...

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Identifiers

PMID: 34493746
DOI: 10.1038/s41598-021-97133-6
PMCID: PMC8423799

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